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Discover NAN’s Breakthrough 5-MO: Helping Support Your Child’s Immunity

Mar 23, 2026
3 mins

Every parent wants to give their child the best, especially when it comes to supporting a healthy immune system. At Nestlé, years of research in pediatric nutrition have led to a breakthrough ingredient now found across our NAN Optipro 3 and NAN Supremepro HA3 ranges: 5‑MO Complex™, a unique blend of five milk oligosaccharides (MOs).

These MOs—2’-FL, DFL, LNT, 3’-SL and 6’-SL—are special carbohydrates also found in milk, and they play an important role in helping support a child’s natural defenses. Both NAN Optipro3 and NAN Supremepro H.A.3 are the first and only growing‑up milk formulas to offer this exclusive blend. This is the first time in history that a milk formula contains MOs from each of the 3 major families.

What Makes 5‑MO Special?

The 5‑MO Complex™ works together with essential nutrients like vitamins A, B12, C, D and folic acid—important for supporting the normal function of your child’s immune system.

These MOs also help by supporting good bacteria in the gut, which is an important part of your child’s natural defenses. NAN Optipro3 and NAN Supremepro HA3 include Bifidus BL, a probiotic that helps keep a healthy balance of beneficial bacteria.

Here are the 4 ways in which Milk Oligosaccharides serve as food for probiotics (good bacteria), supporting your child’s immunity:

1) MOs promote the growth of good bacteria 
For gut microbiota, MOs act as a substrate with powerful and selective action: they act selectively as food for good bacteria such as bifidobacterial which helps them to thrive, while limiting the growth of disease-causing bacteria i.e. potentially pathogenic strains of Enterobacteriaceae, Escherichia coli and Clostridia.

2) MOs strengthens gut barrier function to reduce risk of infection
To cause an infectious disease, pathogens such as bacteria and virus need to bind to the gut lining. MOs can directly interact with cells on the surface of the intestine and change their shape (i.e., glycan expression) in a way that prevents the attachment of disease-causing  pathogens and enhances their removal via clearance in stools.

3) MOs prevent disease-causing bacteria/virus from binding to gut
MOs can be classified into 3 main families based on their structure. Some MOs such as 2’FL, have a surface structure that are similar to receptors on the gut, hence serve as decoy receptors by binding to disease-causing bacteria/viruses. This keeps them away from the gut lining, preventing them from causing infection via gut entry.

4) MOs directly modulates the immune system, reducing risk of allergy
Immune cells known as T-cells can be classified into 2 types: Th1 or Th2. In a young child, his innate immune system is highly inclined towards Th2 response, favoring allergic reactions. MOs can help promote a shift towards a Th1, hence resulting in a more balanced Th1/Th2 response and drive immune maturation, reducing risk of allergic reaction

NAN Optipro3: Gentle Nutrition for Everyday Growth

NAN Optipro3 is designed to support your child’s daily nutritional needs with:

  • 5‑MO Complex™ and Immunity Guardians, a blend of vitamins and minerals that contribute to immune support.
  • Optimized gentle proteins and Bifidus BL probiotics to help maintain digestive health.
  • No added sucrose, keeping to the natural goodness of milk.

This formula is proudly made in Singapore, and crafted to help build a strong foundation for your child.

NAN Supremepro H.A.3: Advanced Hypoallergenic Nutrition

For parents seeking an advanced, hypoallergenic option, NAN Supremepro H.A.3 offers:

  • The same 5‑MO Complex™, making it the first and only formula to combine all five MOs with added immune-supporting nutrients.
  • Gentle OPTIPRO H.A., featuring proteins broken down into smaller pieces to be easier to digest.
  • Higher levels of DHA and ARA to support brain and eye development.
  • Bifidus BL probiotics for digestive health and natural defenses. 

Specially made for the Singapore market, this formulation reflects Nestlé’s continued commitment to high‑quality, science‑backed nutrition.

The NAN Promise

Backed by 160 years of expertise, NAN continues to push the boundaries of nutritional science to support every child’s development. Introducing 5‑MOs reflects our belief that every child deserves access to advanced nutritional innovations. 

With NAN, you’re choosing more than milk—you’re choosing science‑driven support for your child’s immunity and growth.